Alcoholism is a disease that includes alcohol craving and continued drinking despite repeated alcohol-related problems, such as losing a job or getting into trouble with the law. Ondansetron works in the stomach to block the … It is soluble in saline (0.9% w/v) to about 8 mg/mL. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media Study record managers: refer to the Data Element Definitions if submitting registration or results information. It’s in a class of medicines called serotonin 5-HT 3 receptor antagonists. Eligible subjects will be randomized to ondansetron (4 ug/kg) and olanzapine (9, 18, 36 ug/kg) vs placebo. Being treated with any medication with potential for clinically significant interactions with alcohol or olanzapine and/or ondansetron. So while there is no drug-drug interaction between Zofran and alcohol, the additive side effects can be concerning. These studies combined the use of Zofran and alcohol with no serious adverse events reported. If hepatitis is suspected, a hepatitis antibody/antigen screen will be done. This is a double-blind placebo-controlled study. DISCOUNT ONLY – NOT INSURANCE. While Zofran is typically very well tolerated, it can cause mild sedation, fatigue and constipation. There are 633 drug interactions with ketamine / midazolam / ondansetron. [ Time Frame: Throughout the study ], The combination of ondansetron and olanzapine will be superior to placebo at reducing the psychosocial consequences of drinking. Both levomepromazine and alcohol can have CNS depressant effects, which might affect the ability to perform skilled tasks (see 'Drugs and Driving' in Guidance on Prescribing ). Learn about drug interactions between fluoxetine oral and ondansetron oral and use the RxList drug interaction checker to check drug combinations. Talk with your doctor and family members or friends about deciding to join a study. Please remove one or more studies before adding more. Ondansetron is metabolised by multiple hepatic cytochrome P-450 enzymes: CYP3A4, CYP2D6 and CYP1A2. Zofran can thus increase the sedative effect of alcohol, and further augment some performance changes induced by the peculiar stimulant activity of drinking . These include:, serotonin antagonists (e.g., ritanserin or buspirone), dopamine antagonists (e.g., haloperidol), or compounds with … In our latest question and answer, we discuss the safety considerations when combining alcohol with Zofran (ondansetron). Specific studies have shown that ondansetron does not interact with alcohol, temazepam, furosemide, alfentanil, tramadol, morphine, lignocaine, propofol and thiopental. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Ondansetron competes for the 5-HT3 (serotonin) binding sites on nerve cells in the gastrointestinal tract or the central nervous system. Ondansetron is believed to work by blocking the effects of serotonin. I got it prescribed for nausea. These include:, serotonin antagonists (e.g., ritanserin or buspirone), dopamine antagonists (e.g., haloperidol), or compounds with actions similar to disulfiram (Antabuse®). Both ondansetron and St John's wort can increase the risk of serotonin syndrome. See 'Serotonin syndrome' and 'Monoamine-oxidase inhibitor' under Antidepressant drugs in BNF for more information and for specific advice on avoiding monoamine-oxidase inhibitors during and after administration of other serotonergic drugs. There are 16 disease interactions with ketamine / midazolam / ondansetron which include: acute alcohol intoxication; closed-angle glaucoma; respiratory depression; seizures Interestingly enough, use the of Zofran has been investigated for the treatment of alcoholism. Keywords provided by University of Virginia: Why Should I Register and Submit Results? Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00678457. Eligible subjects will be randomized to ondansetron (4 ug/kg) and olanzapine (9, 18, 36 ug/kg) vs placebo. Ondansetron With Olanzapine for the Treatment of Alcohol Dependence: A Preliminary Clinical Trial: Official Title: Ondansetron With Olanzapine for the Treatment of Alcohol Dependence: A Preliminary Clinical Trial: Brief Summary: This study would like to test whether the combination of ondansetron and olanzapine will be Ondansetron, a 5-HT(3) receptor antagonist, has been reported to have proconvulsant and anticonvulsant effects in animals. Interactions with Ondansetron Hydrochloride If you use other drugs or over the counter products at the same time, the effects of Ondansetron Hydrochloride may change. Ketamine / midazolam / ondansetron disease interactions. Ondansetron orally disintegrating tablet can interact with other medications, vitamins, or herbs you may be taking. Discounts are available exclusively through participating pharmacies. [ Time Frame: Throughout the study ], Males and females who have given written informed consent, Aged 18 years and above and weighing ≥40 kg and ≤140 kg, Drinking on average ≥21 and ≥28 drinks/week for women and men, respectively, in the 7-day period prior to enrollment, Good physical health as determined by a complete physical examination, electrocardiogram (EKG) within normal limits and laboratory screening tests within acceptable range, Literate in English and able to read, understand, and complete the rating scales and questionnaires accurately, follow instructions, and make use of the behavioral treatments, Willing to participate in behavioral treatments for alcoholism, Answer an advertisement in the newspaper/radio/television, and express a wish to stop drinking, Provide evidence of stable residence in the last month prior to enrollment in the study, and have no plans to move in the next three months, Any current axis I DSM-IV psychiatric disorder other than alcohol or nicotine dependence that warrants treatment or would preclude safe participation in the protocol, Severe alcohol withdrawal symptoms that, in the physician's opinion, require inpatient treatment, Serious medical comorbidity requiring medical intervention or close supervision, or any condition that can interfere with the receipt of ondansetron or olanzapine, Severe or life-threatening adverse reactions to the ondansetron or olanzapine medications in the past or during this clinical trial, Female subjects who are pregnant, lactating, or not adhering to an acceptable form of contraception at any time during the study, Received inpatient or outpatient treatment for alcohol dependence within the last 30 days. A total of 70 outpatients with alcohol use disorder and BPD, cyclothymic disorder, schizoaffective disorder (bipolar type), or MDD with mixed features will be enrolled in a 12-week, randomized, double-blind, parallel-group, placebo-controlled study of ondansetron. Please feel free to reach out to him directly if you have any inquiries or want to connect! Majority of the parenteral solutions use Benzyl alcohol as a preservative. Choosing to participate in a study is an important personal decision. Ondansetron had minimal effects on subjects receiving placebo alcohol. To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Chemical or pharmacologic interactions occur through a wide variety of mechanisms. This study would like to test whether the combination of ondansetron and olanzapine will be superior to placebo at decreasing self-reported heavy drinking among early onset alcoholics. It is also specifically used for the prevention of nausea while on chemotherapy or radiation therapy. It is possible that unknown interactions exist. Answer. He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! This may increase your risk for side-effects or cause your drug not to work properly. Alcohol Both levomepromazine and alcohol can increase the risk of hypotension. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Zofran It works as as serotonin receptor antagonist. Drug: Olanzapine The blocking of these receptors can lessen or eliminate symptoms of nausea and vomiting. I have using Cepacol drops for a bad sore throat. If possible, quit drinking alcohol in order to increase your health and strengthen your immune system. It can cause myriad health problems, including cirrhosis of the liver, birth defects, heart disease, stroke, psychological problems, and dementia. Emtricitabine; Rilpivirine; Tenofovir alafenamide: (Major) Due to a possible risk for QT prolongation and torsade de pointes (TdP), ondansetron and rilpivirine should be used together cautiously. Ondansetron is a medicine used to prevent nausea and vomiting caused by surgery or cancer treatments. Zofran is a medication used for the treatment of nausea and vomiting. Current infective hepatitis as evidenced by clinical manifestations. Read more about the prescription drug ONDANSETRON - ORAL. Can you drink alcohol while taking Zofran (ondansetron)? The use of benzyl alcohol as a 5% solution has been approved by the US FDA in the treat-ment of head lice in children older than 6 months and in adults. In addition, Zofran has been known to increase the likelihood of headaches. Consumer information about the medication ONDANSETRON - ORAL (Zofran), includes side effects, drug interactions, recommended dosages, and storage information. Ondansetron produced significant reductions in craving in the early-onset group, but not the late-onset alcoholics. There are side effects of ondansetron including drowsiness, headache, and diarrhea. It is also used to prevent nausea and vomiting that may occur after surgery. It is sparingly soluble in water and in alcohol, soluble in methanol and slightly soluble in methylene chloride. Make Mayani Dental your Boston dentist and have confidence your smile brings you happiness. Dexamethasone Interactions with Food and Herbs Grapefruit and pomegranate juice: Dexamethasone is a corticosteroid that interacts with both grapefruit and pomegranate juice. Experimental studies suggest that 5-hydroxytryptamine (5-HT) receptors play a role in epileptogenesis and seizure propagation. For general information, Learn About Clinical Studies. For non-prescription products, read the label or package ingredients carefully. Ondansetron is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy), radiation treatment, or drugs used to put you to sleep before surgery.Ondansetron works by blocking one of the body's natural substances that causes vomiting.Ondansetron is available under the following different brand names: Zofran, Zofran ODT, … Due to the multiplicity of metabolic enzymes capable of metabolising Diagnosis or suspicion of Alzheimer's disease, Clinically significant abnormalities on the EKG that will preclude safe participation. 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